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Borna Disease Virus and Human Disease

机译:博尔纳病病毒和人类疾病

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摘要

The biology of Borna disease virus (BDV) strongly supports the likelihood of human infection with BDV or a variant of BDV. Thus far, the evidence supporting BDV infection in humans has initiated much controversy among basic and clinical scientists; only time and additional research will support or refute the hypothesis of human BDV infection. Until an assay of acceptable specificity and sensitivity has been developed, validated, and used to document human BDV infection, scientists cannot reasonably begin to associate BDV infection with specific disease syndromes. Clinical studies seeking causal associations between BDV infection and specific diseases must ensure the proper identification of the BDV infection status of patients and control subjects by using a validated, highly sensitive, and highly specific assay (or series of assays). For clinical studies, a highly sensitive “screening” test followed by a highly specific confirmatory test will be of significant benefit. Although it is possible to formulate hypotheses about the clinical outcomes of human BDV infection based on animal model work, to date no human disease has been causally linked to human BDV infection. Scientists all over the world are actively pursuing these issues, and with continuing advances in clinical and basic BDV research, the answers cannot be far away.
机译:博尔纳病病毒(BDV)的生物学特性强烈支持人类感染BDV或BDV变异体的可能性。迄今为止,支持人类BDV感染的证据已在基础和临床科学家中引发了许多争议。只有时间和其他研究才能支持或驳斥人类BDV感染的假说。在开发,验证并用于记录人类BDV感染的可接受的特异性和敏感性的测定方法之前,科学家们无法合理地开始将BDV感染与特定的疾病综合征相关联。寻求BDV感染与特定疾病之间因果关系的临床研究必须通过使用经过验证的,高度敏感和高度特异性的检测方法(或一系列检测方法)来确保正确识别患者和对照对象的BDV感染状况。对于临床研究,高度敏感的“筛选”测试,然后进行高度特异性的确认测试,将具有显着优势。尽管有可能根据动物模型工作提出有关人类BDV感染临床结果的假设,但迄今为止,还没有人类疾病与人类BDV感染有因果关系。全世界的科学家都在积极地追求这些问题,并且随着临床和基础BDV研究的不断进步,答案不可能遥不可及。

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  • 作者

    Carbone, Kathryn M.;

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  • 年度 2001
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  • 原文格式 PDF
  • 正文语种 en
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